Endocrine Abstracts

Introduction: Iodine nutrition is critical for human health. In recent years the main focus was on the developing brain during pregnancy. In addition, iodine nutrition is essential for growth and development during adolescence. Iodine nutrition was recently low within the recommended range among adult Faroese living on local, iodine-rich marine food items. Dietary habits among young generations are drifting away from local foods, and this raises a concern that led us to perfor...

Background: Pheochromocytoma (Pheo) is a tumor deriving from chromaffin cells. It can be studied using 18F-dihydroxyphenylalanine (DOPA) - positron emission tomography (PET) due to its overexpression of L-type amino acid transporters (LAT1 and LAT2). The oncogenic pathways involved are still poorly understood. This study examined the relationship between 18F-DOPA-PET uptake and LAT1 expression, and explored the role of miR-375 and putative target genes.</...

Background: Vitamin D supplementation is an integral component of treating patients with osteoporosis/osteopenia. Data have shown that monthly vitamin D supplementation is not inferior to daily regarding target vitamin D levels. Moreover, it has been argued that monthly supplementation might increase adherence. Patients’ adherence and satisfaction with daily versus monthly vitamin D supplementation have been hardly investigated. The current study evaluated osteopenic/oste...

Introduction: Several formulas are described to calculate the Insulin Dose to start insulin pump therapy. However, there are no data demonstrating their effectiveness in achieving good glycemic control.Aim: To assess the Total Daily Dose of Insulin (TDDI) at 3 months after beginning an insulin pump, and determine which formula most closely matches the TDDI required in cases where good glycemic control is achieved after that period....

Struma ovarii is a form of mature teratoma, a rare germ cell tumor, containing more than 50% thyroid tissue. Malignancy is uncommon. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) inside struma ovarii was never described. A 32 y.o. female with previous history of ovarian cysts was admitted in the emergency room with painfull acute abdominal distention. The MRI revealed a right adnexal mass, predominantly cystic with 82x66x80 mm and surrou...

Background and objective: Multiple Endocrine Neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by a broad clinical spectrum. Previous multi-center studies, that analyzed large groups of patients with MEN 1 have been reported before but long term follow up data of these patients focusing exclusively on primary hyperparathyroidism (PHPT) are scarce.Patients and Methods: In this retrospective cohort study we include all patients with P...

Background: Endoscopic surgery (ES) performed in Pituitary Centers of Excellence (PCOE) represents the gold standard treatment for GH-secreting adenomas. However, rate of cure greatly varies according to definition criteria, follow-up duration, various patient and adenoma features, and surgeon ability.Study aim: To assess short- (3 month) and long-term (≥1 year) outcome and identify predictors of ES, in a large and homogeneous cohort of acromegaly ...

Introduction: Graves orbitopathy (GO) is an inflammatory condition of the orbital fat and muscles and affect 30-50% of patients with Graves’ disease. The first-line treatment of moderate to severe GO according to EUGOGO is intravenous glucocorticoids, but 20-30% of the cases appear to be corticosteroid resistant or refractory. Promising results have been described with Tocilizumab (TCZ) as a second-line moderate to severe GO treatment.Case presentat...

Introduction Severe infection from the SARS-CoV-2 virus is associated with various manifestations, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may be related to fatalities. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is con...

Introduction: The prevalence of lymph node metastasis from micropapillary thyroid carcinoma (mPTC) in different studies is up to 33%. Preoperative diagnosis of central lymph node (CLN) metastasis is essential for the surgical management of those patients. Prophylactic CLN dissection for patients with mPTC is controversial. Our study aimed to assess the prevalence and the risk factors of LMN metastasis in patients mPTC Methods: We retrospectively study th...